WE DELIVER EXPERTISE IN COMPUTER-AIDED DRUG DESIGN

Guesswork in drug discovery can be costly and time consuming. Our team is here to remove that barrier for you. With us, your team gets:

  • Significantly enhanced visualization of novel binding sites of a protein being targeted for development of a new drug.
  • Unprecedented levels of detail using the SilcsBio computational physics-based algorithms for mapping proteins.
  • Superiorly designed small molecules optimized for affinity, specificity, and drug-like properties.
  • Maximized atomic interactions between ligand and target, using the SilcsBio drug design platform to reveal where changes can be made to boost drug-like properties without sacrificing affinity or specificity.
  • Facilitated formulation of biologics through comprehensive excipient and protein-protein interaction mapping.

EXPERT SERVICES

The SilcsBio team provides expert services to make your structure-based drug design program more efficient, with increased speed and reduced costs.

We will put our software to work for you, collaborating closely with you and your team – to execute on and deliver results for your drug discovery projects.

It’s our priority to ensure we have a constant, open dialogue with our customers to understand and act on their specific research needs and objectives.

For small and mid-size pharmaceutical and life science research institutions, our team provides expertise and advanced computational resources for:

Target Mapping

Hit Identification and Expansion

Lead Compound
Optimization

Allosteric Binding Site
Identification & Targeting

Force Field Development

In Silico Biologics
Formulation

Binding Hotspot
Identification

Single-Step FEP

Protein-Protein
Interaction Targeting

GPCR Targeting

Molecular Dynamics
Simulations

Homology Modeling

THE SILCS APPROACH

Patented SILCS technology works in tandem with SILCS-Biologics, CGenFF, and SSFEP for end-to-end drug design workflow or at any point in the drug design process – from hit identification to lead optimization.

01
01

Target Analysis and Mapping

  • SILCS-FragMaps
  • SILCS-Hotspot
02
02

SILCS in silico Screening

  • SILCS-Pharm
  • SILCS Docking (SILCS-MC)
  • MD Simulations (CGenFF)
  • Ligand-based QSAR
03
03

Hit Confirmation

  • Experimental Confirmation
04
04

Hit Expansion

  • Similarity Screen
  • SILCS-MC Ranking and Target Specificity
  • Drug-like-ness
  • HSA Binding
  • P450 Enzyme Binding
05
05

Expansion Confirmation

  • Experimental Confirmation
06
06

Lead Optimization

  • SILCS-MC
  • SSFEP

ACCELERATE YOUR RESULTS WITH SILCSBIO

Connect with us today to learn more about how we can help your team work faster and more efficiently.

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