We deliver expertise in computer-aided drug design

With SilcsBio’s computer-aided drug design tools and team expertise, drug discovery scientists get:

  • Significantly enhanced visualization of novel binding sites of a protein being targeted for development of a new drug.
  • SilcsBio’s computational physics-based algorithms for mapping proteins provide researchers with unprecedented levels of detail.
  • Superiorly designed small molecules optimized for affinity, specificity, and drug-like properties.
  • SilcsBio’s drug design platform helps you maximize atomic interactions between ligand and target and reveals where changes can be made to maximize drug-like properties without sacrificing affinity or specificity.
  • SilcsBio’s technology facilitates the formulation of biologics through comprehensive excipient and protein-protein interaction mapping.

Our expert services and consulting make your structure-based drug design program more efficient, with increased speed and reduced costs.

Our method of consulting services – deployment of our software for live research projects – gives us the opportunity to interact closely with our customers.

Our priority is ensuring we have a constant, open dialogue with our customers to understand and act on their specific research needs and objectives.

SilcsBio’s accurate 3-D free energy maps “FragMaps” account for conformational nuances to reveal hidden pockets of opportunity, further enabling your drug discovery team to:

  • Accurately interpret results from biological assays
  • Enhance high throughput screening to drive hit selection
  • Reduce drug development costs
  • Bolster drug development pipelines

For small and mid-size pharmaceutical and life science research institutions, our team provides direct, specialized expertise and advanced computational resources for:

  • Target Mapping -> Lead Candidate Design
  • Lead Compound Optimization
  • Protein-Protein Interaction Targeting
  • Allosteric Binding Site Identification and Targeting
  • GPCR Targeting
  • CGenFF: Force Field Development
  • Molecular Dynamics Simulations
  • In Silico Biologics Formulation (SILCS-Biologics)
  • Homology Modeling