Cracking KRAS G12D with SILCS: From Binding Site Prediction to Ligand Ranking
High-throughput, physics-based simulations delivering near-FEP accuracy, interpretability, and speed — a retrospective study on the challenging KRAS G12D target. KRAS mutations—especially the G12D variant—are among the most high-value, but historically “undruggable,” targets in oncology. Understanding where ligands bind, how strongly they bind, and how structural modifications affect affinity is [...]
We’re Hiring: Sales Manager
As Sales Manager for SilcsBio, you will be the driving force behind our revenue growth, responsible for connecting researchers and pharmaceutical innovators with our advanced molecular modeling tools and services.
What’s New in SILCS v2025: Enhancing Precision in Computer-Aided Drug Design
We recently hosted our SILCS v2025 Release Webinar, showcasing the latest advancements in our cutting-edge molecular modeling platform. If you missed it, now’s your chance to catch up! SILCS v2025 brings major enhancements to accuracy, usability, and flexibility, enabling researchers to accelerate drug discovery like never before. From enhanced SILCS-MC [...]
Webinar: SILCS-WATER Accounting for the Role of Water in Protein Ligand Binding
SilcsBio hosted a webinar on January 7, 2025 showcasing how SILCS-WATER is revolutionizing protein-ligand binding analysis by integrating the influence of water molecules in your drug discovery workflow. About SILCS-WATER Water molecules are integral to protein-ligand interactions, affecting binding orientation, affinity, and overall dynamics. SILCS-WATER brings this critical element into [...]
Introducing SilcsBio Version 2024.2: A GUI Update!
We are thrilled to unveil SilcsBio Version 2024.2, a dedicated update focusing exclusively on enhancing our Graphical User Interface (GUI). This release is packed with features designed to make your molecular visualization and analysis more intuitive and efficient. See below for all the new features. Learn More About the Update: For [...]
Exciting News from SilcsBio: Introducing the CGenFF Web App!
We are thrilled to announce the launch of the CGenFF Web App by SilcsBio. To celebrate this milestone, we recently hosted a webinar that delved into the capabilities and applications of the CGenFF platform. What is CGenFF? CGenFF, short for CHARMM General Force Field, represents a force field parameterization program [...]
