Computational Characterization of Antibody–Excipient Interactions for Rational Excipient Selection Using the Site Identification by Ligand Competitive Saturation-Biologics Approach

SILCS-Biologics combines the accuracy of the SILCS ligand docking and protein-protein interaction technologies to allow for comprehensive mapping of the binding locations and affinities of excipients on the entire surface of protein therapeutics including monoclonal antibodies (mAb).  Application of the SILCS-Biologics approach to the NIST mAb identified calculated SILCS metrics for a collection of eight […]

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