Small-molecule inhibitors of ERK-mediated immediate early gene expression and proliferation of melanoma cells expressing mutated BRafJune 1, 2018
Therapeutic targeting of GCB- and ABC-DLBCLs by rationally designed BCL6 inhibitors
Acyl-2-aminobenzimidazoles: A novel class of neuroprotective agents targeting mGluR5
Cyclopropyl-containing positive allosteric modulators of metabotropic glutamate receptor subtype 5
SILCS-MC ranks top 10 on Free Energy Set 1 in the D3R Grand Challenge 2 on FXRMarch 26, 2018Grand Challenge 2 from D3R provided a farnesoid X receptor (FXR) target dataset to participants, which was used to test the performance of various computational approaches. SilcsBio’s SILCS-MC approach ranked 4th in Stage 1 and 6th in Stage 2 on...
Iminoguanidines as Allosteric Inhibitors of the Iron-Regulated Heme Oxygenase (HemO) of Pseudomonas aeruginosaSeptember 21, 2017
Excipient Design for Protein-Based DrugsSeptember 9, 2017Fall 2017 ACS : Excipient Design for Protein-Based Drugs View Poster
Rapid Evaluation of Relative Change in Binding Affinity Using Single Step Free Energy Perturbation (SSFEP)Fall 2017 ACS View Poster
SilcsBio, LLC Announces Release of CGenFF 2.1.0March 4, 2017Baltimore, MD, 4 March 2017 In ongoing efforts to improve the coverage of the CGenFF program, version 2.1.0 of the CGenFF program extends support to the S-P bond found in the GTP-gamma like molecules. Bonded parameters and charge-distribution along...