SilcsBio | Visualizing Computer-Aided Drug Design

Visualize Drug Design in a Whole New Way

SilcsBio provides computer-aided drug design solutions that dramatically accelerate and improve small molecule and biologic drug discovery pipelines.

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SilcsBio Response to Covid-19

SilcsBio has created a FragMap library of many of the proteins of the Covid-19 virus to drive your drug discovery efforts.

Covid-19 Main Protease FragMap

The SilcsBio Difference

Services

Our experts provide consultation and training, paired with guided deployment of the SILCS platform technology, to enable drug discovery teams to work faster and more productively.

Software

Patented SILCS technology works in tandem with SILCS-Biologics, CGenFF, and SSFEP for targeted solutions or complete end-to-end drug design workflow — from hit identification to lead optimization.

Platform

Our proprietary CADD software technology, SILCS, allows researchers to visualize and interact with 3D maps of protein surfaces for drug design.

SILCS

Site-Identification by Ligand Competitive Saturation

Our proprietary CADD software technology, SILCS, generates highly accurate 3D free energy maps called “FragMaps” which account for conformational nuances to reveal hidden pockets of opportunity.

SILCS FragMaps technology gives you an intuitive way of interacting with and visualizing the entire protein surface, further enabling your drug discovery team to:

Accelerate drug discovery timelines
Enhance high throughput screening to drive hit selection
Reduce drug development costs
Bolster drug development pipelines

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Why SilcsBio outperforms all others

SILCS is built on rigorous free energy calculations employing:

Multiple small molecule probes with diverse functional groups
Explicit solvent modeling
Target molecule flexibility
Advanced sampling methods (GCMC/MD) to identify cryptic pockets

The proof is in the details

Publications

Our Team

Our team is committed to delivering the fastest, most reliable drug designs for your highest value drug programs. We are committed to providing our expertise and technology to unlock a whole new world of possibilities for you and your team.

Meet Our Team

Our Partners and Collaborators

News

New Peer Reviewed Article Demonstrates SilcsBio, LLC’s Performance

New Peer Reviewed Article Demonstrates SilcsBio, LLC’s Performance Baltimore, Maryland, 4 November 2016 Recently published research has found that SilcsBio’s product, single-step free energy perturbation (SSFEP), demonstrated equal or more accurate results than standard free energy perturbation (FEP) but a thousand times faster. Additionally, SilcsBio’s site-identification by ligand competitive saturation (SILCS) product yielded relative free […]

FOR IMMEDIATE RELEASE: July 12, 2018 Ken Malone SilcsBio, LLC 410.929.2305 Ken.Malone@silcsbio.com SilcsBio, LLC Announces Issuance of US Patent with Utility in Drug Design Software July 12, 2018 Baltimore, Maryland: SilcsBio, LLC (SilcsBio) announced today the issuance of a US patent covering key elements of SilcsBio’s drug design software. The SilcsBio software is broadly used […]

Baltimore, MD, 15 November 2016 Version 2.0.0 is the second release of CGenFF program, extending support to a larger variety of drug-like molecules to be used routinely in Computer-Aided Drug Design projects. Specifically, it improves treatment of halogen bonds, by introducing lone-pairs onto the halogen atoms of aromatic systems. Additionally, support is now extended to […]